Publications


  1. Gauthier, S, Herrmann, N, Rosa-Neto, P. Optimal use of cholinergic drugs in Alzheimer's disease. Brain. 2018; :. doi: 10.1093/brain/awy204. PubMed PMID:30084978 .
  2. Pascoal, TA, Shin, M, Kang, MS, Chamoun, M, Chartrand, D, Mathotaarachchi, S et al.. In vivo quantification of neurofibrillary tangles with [18F]MK-6240. Alzheimers Res Ther. 2018;10 (1):74. doi: 10.1186/s13195-018-0402-y. PubMed PMID:30064520 PubMed Central PMC6069775.
  3. Guadagno, A, Kang, MS, Devenyi, GA, Mathieu, AP, Rosa-Neto, P, Chakravarty, M et al.. Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress. Brain Struct Funct. 2018; :. doi: 10.1007/s00429-018-1720-3. PubMed PMID:30032360 .
  4. Zukotynski, K, Kuo, PH, Mikulis, D, Rosa-Neto, P, Strafella, AP, Subramaniam, RM et al.. PET/CT of Dementia. AJR Am J Roentgenol. 2018;211 (2):246-259. doi: 10.2214/AJR.18.19822. PubMed PMID:29949415 .
  5. Smart, K, Cox, SML, Nagano-Saito, A, Rosa-Neto, P, Leyton, M, Benkelfat, C et al.. Test-retest variability of [11 C]ABP688 estimates of metabotropic glutamate receptor subtype 5 availability in humans. Synapse. 2018; :e22041. doi: 10.1002/syn.22041. PubMed PMID:29935121 .
  6. Gauthier, S, Zhang, H, Ng, KP, Pascoal, TA, Rosa-Neto, P. Impact of the biological definition of Alzheimer's disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?. Transl Neurodegener. 2018;7 :12. doi: 10.1186/s40035-018-0117-9. PubMed PMID:29876101 PubMed Central PMC5977549.
  7. Meyer, PF, Savard, M, Poirier, J, Labonté, A, Rosa-Neto, P, Weitz, TM et al.. Bi-directional Association of Cerebrospinal Fluid Immune Markers with Stage of Alzheimer's Disease Pathogenesis. J. Alzheimers Dis. 2018;63 (2):577-590. doi: 10.3233/JAD-170887. PubMed PMID:29660934 PubMed Central PMC5929310.
  8. Gauthier, S, Ng, KP, Pascoal, TA, Zhang, H, Rosa-Neto, P. Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment. J. Alzheimers Dis. 2018;64 (s1):S23-S31. doi: 10.3233/JAD-179924. PubMed PMID:29504543 PubMed Central PMC6004905.
  9. Villeneuve, S, Vogel, JW, Gonneaud, J, Pichet Binette, A, Rosa-Neto, P, Gauthier, S et al.. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease. JAMA Neurol. 2018;75 (5):608-619. doi: 10.1001/jamaneurol.2017.5135. PubMed PMID:29482212 PubMed Central PMC5885216.
  10. Benedet, AL, Yu, L, Labbe, A, Mathotaarachchi, S, Pascoal, TA, Shin, M et al.. CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem. Neurol Genet. 2018;4 (1):e216. doi: 10.1212/NXG.0000000000000216. PubMed PMID:29473050 PubMed Central PMC5820598.
  11. Therriault, J, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Kang, MS, Struyfs, H et al.. Anosognosia predicts default mode network hypometabolism and clinical progression to dementia. Neurology. 2018;90 (11):e932-e939. doi: 10.1212/WNL.0000000000005120. PubMed PMID:29444971 PubMed Central PMC5858945.
  12. Pascoal, TA, Mathotaarachchi, S, Shin, M, Park, AY, Mohades, S, Benedet, AL et al.. Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging. 2018;45 (6):1021-1030. doi: 10.1007/s00259-018-3933-3. PubMed PMID:29396637 PubMed Central PMC5915512.
  13. Henriques, AD, Benedet, AL, Camargos, EF, Rosa-Neto, P, Nóbrega, OT. Fluid and imaging biomarkers for Alzheimer's disease: Where we stand and where to head to. Exp. Gerontol. 2018;107 :169-177. doi: 10.1016/j.exger.2018.01.002. PubMed PMID:29307736 .
  14. Bernard-Gauthier, V, Mossine, AV, Mahringer, A, Aliaga, A, Bailey, JJ, Shao, X et al.. Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging. J. Med. Chem. 2018;61 (4):1737-1743. doi: 10.1021/acs.jmedchem.7b01607. PubMed PMID:29257860 .
  15. Tardif, CL, Devenyi, GA, Amaral, RSC, Pelleieux, S, Poirier, J, Rosa-Neto, P et al.. Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease. Hum Brain Mapp. 2018;39 (2):971-984. doi: 10.1002/hbm.23897. PubMed PMID:29164798 .
  16. Li, X, Ba, M, Ng, KP, Mathotaarachchi, S, Pascoal, TA, Rosa-Neto, P et al.. Characterizing biomarker features of cognitively normal individuals with ventriculomegaly. Alzheimers Dement (Amst). 2018;10 :12-21. doi: 10.1016/j.dadm.2017.08.001. PubMed PMID:29159265 PubMed Central PMC5678356.
  17. Parent, MJ, Zimmer, ER, Shin, M, Kang, MS, Fonov, VS, Mathieu, A et al.. Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities. J. Neurosci. 2017;37 (50):12263-12271. doi: 10.1523/JNEUROSCI.1346-17.2017. PubMed PMID:29097597 PubMed Central PMC5729194.
  18. Gauthier, S, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chung, CO, Benedetti, AL et al.. Author response: Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017;89 (18):1931. doi: 10.1212/WNL.0000000000004593. PubMed PMID:29084927 .
  19. Ba, M, Li, X, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Rosa-Neto, P et al.. The prevalence and biomarkers' characteristic of rapidly progressive Alzheimer's disease from the Alzheimer's Disease Neuroimaging Initiative database. Alzheimers Dement (N Y). 2017;3 (1):107-113. doi: 10.1016/j.trci.2016.12.005. PubMed PMID:29067322 PubMed Central PMC5651370.
  20. Tuwaig, M, Savard, M, Jutras, B, Poirier, J, Collins, DL, Rosa-Neto, P et al.. Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer's Disease. J. Alzheimers Dis. 2017;60 (4):1589-1600. doi: 10.3233/JAD-170545. PubMed PMID:28984583 PubMed Central PMC5757649.
  21. Aghourian, M, Legault-Denis, C, Soucy, JP, Rosa-Neto, P, Gauthier, S, Kostikov, A et al.. Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV. Mol. Psychiatry. 2017;22 (11):1531-1538. doi: 10.1038/mp.2017.183. PubMed PMID:28894304 .
  22. Mathotaarachchi, S, Pascoal, TA, Shin, M, Benedet, AL, Kang, MS, Beaudry, T et al.. Identifying incipient dementia individuals using machine learning and amyloid imaging. Neurobiol. Aging. 2017;59 :80-90. doi: 10.1016/j.neurobiolaging.2017.06.027. PubMed PMID:28756942 .
  23. Bernard-Gauthier, V, Bailey, JJ, Mossine, AV, Lindner, S, Vomacka, L, Aliaga, A et al.. A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human. J. Med. Chem. 2017;60 (16):6897-6910. doi: 10.1021/acs.jmedchem.7b00396. PubMed PMID:28696690 .
  24. Lafaille-Magnan, ME, Poirier, J, Etienne, P, Tremblay-Mercier, J, Frenette, J, Rosa-Neto, P et al.. Odor identification as a biomarker of preclinical AD in older adults at risk. Neurology. 2017;89 (4):327-335. doi: 10.1212/WNL.0000000000004159. PubMed PMID:28659431 PubMed Central PMC5574678.
  25. Engelborghs, S, Niemantsverdriet, E, Struyfs, H, Blennow, K, Brouns, R, Comabella, M et al.. Consensus guidelines for lumbar puncture in patients with neurological diseases. Alzheimers Dement (Amst). 2017;8 :111-126. doi: 10.1016/j.dadm.2017.04.007. PubMed PMID:28603768 PubMed Central PMC5454085.
  26. Dadar, M, Pascoal, TA, Manitsirikul, S, Misquitta, K, Fonov, VS, Tartaglia, MC et al.. Validation of a Regression Technique for Segmentation of White Matter Hyperintensities in Alzheimer's Disease. IEEE Trans Med Imaging. 2017;36 (8):1758-1768. doi: 10.1109/TMI.2017.2693978. PubMed PMID:28422655 .
  27. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chung, CO, Benedet, AL, Shin, M et al.. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017;88 (19):1814-1821. doi: 10.1212/WNL.0000000000003916. PubMed PMID:28404803 PubMed Central PMC5419982.
  28. Chamoun, M, Huppé-Gourgues, F, Legault, I, Rosa-Neto, P, Dumbrava, D, Faubert, J et al.. Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking. Front Hum Neurosci. 2017;11 :128. doi: 10.3389/fnhum.2017.00128. PubMed PMID:28377707 PubMed Central PMC5359296.
  29. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Therriault, J, Kang, MS, Shin, M et al.. Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain. Alzheimers Res Ther. 2017;9 (1):25. doi: 10.1186/s13195-017-0253-y. PubMed PMID:28359327 PubMed Central PMC5374697.
  30. Zimmer, ER, Parent, MJ, Souza, DG, Leuzy, A, Lecrux, C, Kim, HI et al.. [18F]FDG PET signal is driven by astroglial glutamate transport. Nat. Neurosci. 2017;20 (3):393-395. doi: 10.1038/nn.4492. PubMed PMID:28135241 PubMed Central PMC5378483.
  31. Pascoal, TA, Mathotaarachchi, S, Shin, M, Benedet, AL, Mohades, S, Wang, S et al.. Synergistic interaction between amyloid and tau predicts the progression to dementia. Alzheimers Dement. 2017;13 (6):644-653. doi: 10.1016/j.jalz.2016.11.005. PubMed PMID:28024995 .
  32. Tam, A, Dansereau, C, Badhwar, A, Orban, P, Belleville, S, Chertkow, H et al.. A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data Brief. 2016;9 :1122-1129. doi: 10.1016/j.dib.2016.11.036. PubMed PMID:27924300 PubMed Central PMC5128734.
  33. Ba, M, Kong, M, Li, X, Ng, KP, Rosa-Neto, P, Gauthier, S et al.. Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer's disease?. Transl Neurodegener. 2016;5 :20. doi: 10.1186/s40035-016-0067-z. PubMed PMID:27891223 PubMed Central PMC5112745.
  34. Mechling, AE, Arefin, T, Lee, HL, Bienert, T, Reisert, M, Ben Hamida, S et al.. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome. Proc. Natl. Acad. Sci. U.S.A. 2016;113 (41):11603-11608. doi: 10.1073/pnas.1601640113. PubMed PMID:27671662 PubMed Central PMC5068324.
  35. DuBois, JM, Rousset, OG, Guiot, MC, Hall, JA, Reader, AJ, Soucy, JP et al.. Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging. Cereb. Cortex. 2016;26 (11):4170-4179. doi: 10.1093/cercor/bhw249. PubMed PMID:27578494 PubMed Central PMC5066831.
  36. Gibon, J, Kang, MS, Aliaga, A, Sharif, B, Rosa-Neto, P, Séguéla, P et al.. Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. Bioorg. Med. Chem. 2016;24 (19):4759-4765. doi: 10.1016/j.bmc.2016.08.020. PubMed PMID:27567078 .
  37. Turgeon, M, Oualkacha, K, Ciampi, A, Miftah, H, Dehghan, G, Zanke, BW et al.. Principal component of explained variance: An efficient and optimal data dimension reduction framework for association studies. Stat Methods Med Res. 2018;27 (5):1331-1350. doi: 10.1177/0962280216660128. PubMed PMID:27460538 .
  38. Mathotaarachchi, S, Wang, S, Shin, M, Pascoal, TA, Benedet, AL, Kang, MS et al.. VoxelStats: A MATLAB Package for Multi-Modal Voxel-Wise Brain Image Analysis. Front Neuroinform. 2016;10 :20. doi: 10.3389/fninf.2016.00020. PubMed PMID:27378902 PubMed Central PMC4908129.
  39. Cho, J, Kwon, DH, Kim, RG, Song, H, Rosa-Neto, P, Lee, MC et al.. Remodeling of Neuronal Circuits After Reach Training in Chronic Capsular Stroke. Neurorehabil Neural Repair. 2016;30 (10):941-950. doi: 10.1177/1545968316650282. PubMed PMID:27198184 .
  40. Gauthier, S, Rosa-Neto, P, Kass, JS. Ethical Considerations for the Use of Next-Generation Alzheimer Drugs in Symptomatic and At-Risk Patients. Continuum (Minneap Minn). 2016;22 (2 Dementia):615-8. doi: 10.1212/CON.0000000000000306. PubMed PMID:27042911 PubMed Central PMC5390936.
  41. Schilling, LP, Zimmer, ER, Shin, M, Leuzy, A, Pascoal, TA, Benedet, AL et al.. Imaging Alzheimer's disease pathophysiology with PET. Dement Neuropsychol. ;10 (2):79-90. doi: 10.1590/S1980-5764-2016DN1002003. PubMed PMID:29213438 PubMed Central PMC5642398.
  42. Pascoal, TA, Mathotaarachchi, S, Mohades, S, Benedet, AL, Chung, CO, Shin, M et al.. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease. Mol. Psychiatry. 2017;22 (2):306-311. doi: 10.1038/mp.2016.37. PubMed PMID:27021814 PubMed Central PMC5262471.
  43. Laforce, R, Rosa-Neto, P, Soucy, JP, Rabinovici, GD, Dubois, B, Gauthier, S et al.. Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada. Can J Neurol Sci. 2016;43 (4):503-12. doi: 10.1017/cjn.2015.401. PubMed PMID:26916179 .
  44. Tam, A, Dansereau, C, Badhwar, A, Orban, P, Belleville, S, Chertkow, H et al.. Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies. Front Aging Neurosci. 2015;7 :242. doi: 10.3389/fnagi.2015.00242. PubMed PMID:26733866 PubMed Central PMC4689788.
  45. Tomaszewski, S, Gauthier, S, Wimo, A, Rosa-Neto, P. Combination Therapy of Anti-Tau and Anti-Amyloid Drugs for Disease Modification in Early-stage Alzheimer's Disease: Socio-economic Considerations Modeled on Treatments for Tuberculosis, HIV/AIDS and Breast Cancer. J Prev Alzheimers Dis. 2016;3 (3):164-172. doi: 10.14283/jpad.2015.85. PubMed PMID:29205255 .
  46. Kim, RG, Cho, J, Ree, J, Kim, HS, Rosa-Neto, P, Kim, JM et al.. Sensory-parietal cortical stimulation improves motor recovery in severe capsular infarct. J. Cereb. Blood Flow Metab. 2016;36 (12):2211-2222. doi: 10.1177/0271678X15606136. PubMed PMID:26661148 PubMed Central PMC5363658.
  47. Benedet, AL, Labbe, A, Lemay, P, Zimmer, ER, Pascoal, TA, Leuzy, A et al.. Epistasis analysis links immune cascades and cerebral amyloidosis. J Neuroinflammation. 2015;12 :227. doi: 10.1186/s12974-015-0436-z. PubMed PMID:26626881 PubMed Central PMC4666175.
  48. Orban, P, Madjar, C, Savard, M, Dansereau, C, Tam, A, Das, S et al.. Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease. Sci Data. 2015;2 :150043. doi: 10.1038/sdata.2015.43. PubMed PMID:26504522 PubMed Central PMC4603392.
  49. DuBois, JM, Rousset, OG, Rowley, J, Porras-Betancourt, M, Reader, AJ, Labbe, A et al.. Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. Eur. J. Nucl. Med. Mol. Imaging. 2016;43 (1):152-62. doi: 10.1007/s00259-015-3167-6. PubMed PMID:26290423 .
  50. Zimmer, ER, Parent, MJ, Leuzy, A, Aliaga, A, Aliaga, A, Moquin, L et al.. Imaging in vivo glutamate fluctuations with [(11)C]ABP688: a GLT-1 challenge with ceftriaxone. J. Cereb. Blood Flow Metab. 2015;35 (7):1169-74. doi: 10.1038/jcbfm.2015.35. PubMed PMID:25806702 PubMed Central PMC4640271.
  51. Leuzy, A, Zimmer, ER, Dubois, J, Pruessner, J, Cooperman, C, Soucy, JP et al.. In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD. Brain Struct Funct. 2016;221 (3):1387-402. doi: 10.1007/s00429-014-0978-3. PubMed PMID:25596865 .
  52. Zimmer, ER, Leuzy, A, Gauthier, S, Rosa-Neto, P. Developments in Tau PET Imaging. Can J Neurol Sci. 2014;41 (5):547-53. doi: 10.1017/cjn.2014.15. PubMed PMID:25424608 .
  53. Bernard-Gauthier, V, Aliaga, A, Aliaga, A, Boudjemeline, M, Hopewell, R, Kostikov, A et al.. Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents. ACS Chem Neurosci. 2015;6 (2):260-76. doi: 10.1021/cn500193f. PubMed PMID:25350780 .
  54. Cyr, M, Parent, MJ, Mechawar, N, Rosa-Neto, P, Soucy, JP, Clark, SD et al.. Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [¹⁸F]fluoroethoxybenzovesamicol. Behav. Brain Res. 2015;278 :107-14. doi: 10.1016/j.bbr.2014.09.021. PubMed PMID:25257103 .
  55. Zimmer, ER, Parent, MJ, Cuello, AC, Gauthier, S, Rosa-Neto, P. MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research. Trends Neurosci. 2014;37 (11):629-41. doi: 10.1016/j.tins.2014.07.002. PubMed PMID:25151336 .
  56. Zimmer, ER, Leuzy, A, Benedet, AL, Breitner, J, Gauthier, S, Rosa-Neto, P et al.. Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging. J Neuroinflammation. 2014;11 :120. doi: 10.1186/1742-2094-11-120. PubMed PMID:25005532 PubMed Central PMC4099095.
  57. Leuzy, A, Zimmer, ER, Heurling, K, Rosa-Neto, P, Gauthier, S. Use of amyloid PET across the spectrum of Alzheimer's disease: clinical utility and associated ethical issues. Amyloid. 2014;21 (3):143-8. doi: 10.3109/13506129.2014.926267. PubMed PMID:24919109 .
  58. Ongali, B, Nicolakakis, N, Tong, XK, Aboulkassim, T, Papadopoulos, P, Rosa-Neto, P et al.. Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model. Neurobiol. Dis. 2014;68 :126-36. doi: 10.1016/j.nbd.2014.04.018. PubMed PMID:24807206 .
  59. Milella, MS, Marengo, L, Larcher, K, Fotros, A, Dagher, A, Rosa-Neto, P et al.. Limbic system mGluR5 availability in cocaine dependent subjects: a high-resolution PET [(11)C]ABP688 study. Neuroimage. 2014;98 :195-202. doi: 10.1016/j.neuroimage.2014.04.061. PubMed PMID:24795154 .
  60. Zimmer, ER, Leuzy, A, Bhat, V, Gauthier, S, Rosa-Neto, P. In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals. Transl Neurodegener. 2014;3 (1):6. doi: 10.1186/2047-9158-3-6. PubMed PMID:24628994 PubMed Central PMC3995516.
  61. Wu, L, Soder, RB, Schoemaker, D, Carbonnell, F, Sziklas, V, Rowley, J et al.. Resting state executive control network adaptations in amnestic mild cognitive impairment. J. Alzheimers Dis. 2014;40 (4):993-1004. doi: 10.3233/JAD-131574. PubMed PMID:24583406 .
  62. Rosa-Neto, P, Hsiung, GY, Masellis, M, CCDTD4 participants. Fluid biomarkers for diagnosing dementia: rationale and the Canadian Consensus on Diagnosis and Treatment of Dementia recommendations for Canadian physicians. Alzheimers Res Ther. 2013;5 (Suppl 1):S8. doi: 10.1186/alzrt223. PubMed PMID:24565514 PubMed Central PMC3980280.
  63. Burhan, AM, Bartha, R, Bocti, C, Borrie, M, Laforce, R, Rosa-Neto, P et al.. Role of emerging neuroimaging modalities in patients with cognitive impairment: a review from the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012. Alzheimers Res Ther. 2013;5 (Suppl 1):S4. doi: 10.1186/alzrt200. PubMed PMID:24565285 PubMed Central PMC3981649.
  64. Soucy, JP, Bartha, R, Bocti, C, Borrie, M, Burhan, AM, Laforce, R et al.. Clinical applications of neuroimaging in patients with Alzheimer's disease: a review from the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012. Alzheimers Res Ther. 2013;5 (Suppl 1):S3. doi: 10.1186/alzrt199. PubMed PMID:24565260 PubMed Central PMC3980588.
  65. Leuzy, A, Zimmer, ER, Bhat, V, Rosa-Neto, P, Gauthier, S. Imaging biomarkers for amyloid: a new generation of probes and what lies ahead. Int Psychogeriatr. 2014;26 (5):703-7. doi: 10.1017/S1041610214000118. PubMed PMID:24524685 .
  66. Parent, MJ, Bedard, MA, Aliaga, A, Minuzzi, L, Mechawar, N, Soucy, JP et al.. Cholinergic Depletion in Alzheimer's Disease Shown by [ (18) F]FEOBV Autoradiography. Int J Mol Imaging. 2013;2013 :205045. doi: 10.1155/2013/205045. PubMed PMID:24324884 PubMed Central PMC3844185.
  67. Cyr, M, Parent, MJ, Mechawar, N, Rosa-Neto, P, Soucy, JP, Aliaga, A et al.. PET imaging with [¹⁸F]fluoroethoxybenzovesamicol ([¹⁸F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat. Nucl. Med. Biol. 2014;41 (1):96-101. doi: 10.1016/j.nucmedbio.2013.10.004. PubMed PMID:24267056 .
  68. Bernard-Gauthier, V, Boudjemeline, M, Rosa-Neto, P, Thiel, A, Schirrmacher, R. Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one. Bioorg. Med. Chem. 2013;21 (24):7816-29. doi: 10.1016/j.bmc.2013.10.012. PubMed PMID:24183588 .
  69. Gauthier, S, Rosa-Neto, P. Dementia: Disclosure of results to participants in dementia research. Nat Rev Neurol. 2013;9 (11):608-9. doi: 10.1038/nrneurol.2013.213. PubMed PMID:24145370 .
  70. Parent, MJ, Cyr, M, Aliaga, A, Kostikov, A, Schirrmacher, E, Soucy, JP et al.. Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry. EJNMMI Res. 2013;3 (1):70. doi: 10.1186/2191-219X-3-70. PubMed PMID:24103360 PubMed Central PMC3852759.
  71. Rowley, J, Fonov, V, Wu, O, Eskildsen, SF, Schoemaker, D, Wu, L et al.. White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease. PLoS ONE. 2013;8 (9):e74776. doi: 10.1371/journal.pone.0074776. PubMed PMID:24086371 PubMed Central PMC3785512.
  72. Gauthier, S, Leuzy, A, Rosa-Neto, P. How can we improve transfer of outcomes from randomized clinical trials to clinical practice with disease-modifying drugs in Alzheimer's disease?. Neurodegener Dis. 2014;13 (2-3):197-9. doi: 10.1159/000353748. PubMed PMID:23942173 .
  73. Papadopoulos, P, Rosa-Neto, P, Rochford, J, Hamel, E. Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology. PLoS ONE. 2013;8 (7):e68612. doi: 10.1371/journal.pone.0068612. PubMed PMID:23874687 PubMed Central PMC3715495.
  74. Kandratavicius, L, Rosa-Neto, P, Monteiro, MR, Guiot, MC, Assirati, JA Jr, Carlotti, CG Jr et al.. Distinct increased metabotropic glutamate receptor type 5 (mGluR5) in temporal lobe epilepsy with and without hippocampal sclerosis. Hippocampus. 2013;23 (12):1212-30. doi: 10.1002/hipo.22160. PubMed PMID:23804486 PubMed Central PMC4165311.
  75. Gauthier, S, Leuzy, A, Racine, E, Rosa-Neto, P. Diagnosis and management of Alzheimer's disease: past, present and future ethical issues. Prog. Neurobiol. 2013;110 :102-13. doi: 10.1016/j.pneurobio.2013.01.003. PubMed PMID:23578568 .
  76. Gauthier, S, Patterson, C, Chertkow, H, Gordon, M, Herrmann, N, Rockwood, K et al.. Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4). Can Geriatr J. 2012;15 (4):120-6. doi: 10.5770/cgj.15.49. PubMed PMID:23259025 PubMed Central PMC3516356.
  77. Gauthier, S, Patterson, C, Chertkow, H, Gordon, M, Herrmann, N, Rockwood, K et al.. 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. Can J Neurol Sci. 2012;39 (6 Suppl 5):S1-8. . PubMed PMID:23073396 .
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  82. Tong, XK, Lecrux, C, Rosa-Neto, P, Hamel, E. Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits. J. Neurosci. 2012;32 (14):4705-15. doi: 10.1523/JNEUROSCI.0169-12.2012. PubMed PMID:22492027 .
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  84. Kovačević, T, Skelin, I, Minuzzi, L, Rosa-Neto, P, Diksic, M. Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study. Brain Res. Bull. 2012;87 (4-5):406-12. doi: 10.1016/j.brainresbull.2012.01.010. PubMed PMID:22310150 PubMed Central PMC3641045.
  85. Elmenhorst, D, Aliaga, A, Bauer, A, Rosa-Neto, P. Test-retest stability of cerebral mGluR₅ quantification using [¹¹C]ABP688 and positron emission tomography in rats. Synapse. 2012;66 (6):552-60. doi: 10.1002/syn.21542. PubMed PMID:22290765 .
  86. Wu, L, Rosa-Neto, P, Gauthier, S. Use of biomarkers in clinical trials of Alzheimer disease: from concept to application. Mol Diagn Ther. 2011;15 (6):313-25. doi: 10.2165/11595090-000000000-00000. PubMed PMID:22188635 .
  87. Berney, A, Leyton, M, Gravel, P, Sibon, I, Sookman, D, Rosa Neto, P et al.. Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder. Arch. Gen. Psychiatry. 2011;68 (7):732-41. doi: 10.1001/archgenpsychiatry.2011.16. PubMed PMID:21383250 PubMed Central PMC3677917.
  88. Chen, ZJ, He, Y, Rosa-Neto, P, Gong, G, Evans, AC. Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI. Neuroimage. 2011;56 (1):235-45. doi: 10.1016/j.neuroimage.2011.01.010. PubMed PMID:21238595 .
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  90. Ongali, B, Nicolakakis, N, Lecrux, C, Aboulkassim, T, Rosa-Neto, P, Papadopoulos, P et al.. Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease. Am. J. Pathol. 2010;177 (6):3071-80. doi: 10.2353/ajpath.2010.100339. PubMed PMID:21088218 PubMed Central PMC2993264.
  91. Bertomeu, T, Zvereff, V, Ibrahim, A, Zehntner, SP, Aliaga, A, Rosa-Neto, P et al.. TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation. Biochem. Pharmacol. 2010;80 (10):1572-9. doi: 10.1016/j.bcp.2010.07.018. PubMed PMID:20655882 .
  92. Verhaeghe, J, Gravel, P, Mio, R, Fukasawa, R, Rosa-Neto, P, Soucy, JP et al.. Motion compensation for fully 4D PET reconstruction using PET superset data. Phys Med Biol. 2010;55 (14):4063-82. doi: 10.1088/0031-9155/55/14/008. PubMed PMID:20601774 .
  93. Nicolakakis, N, Aboulkassim, T, Aliaga, A, Tong, XK, Rosa-Neto, P, Hamel, E et al.. Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone. J. Cereb. Blood Flow Metab. 2011;31 (1):200-11. doi: 10.1038/jcbfm.2010.78. PubMed PMID:20571524 PubMed Central PMC3049484.
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  95. Elmenhorst, D, Minuzzi, L, Aliaga, A, Rowley, J, Massarweh, G, Diksic, M et al.. In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688. J. Cereb. Blood Flow Metab. 2010;30 (8):1538-49. doi: 10.1038/jcbfm.2010.65. PubMed PMID:20531460 PubMed Central PMC2949244.
  96. Bellec, P, Rosa-Neto, P, Lyttelton, OC, Benali, H, Evans, AC. Multi-level bootstrap analysis of stable clusters in resting-state fMRI. Neuroimage. 2010;51 (3):1126-39. doi: 10.1016/j.neuroimage.2010.02.082. PubMed PMID:20226257 .
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  98. la Fougère, C, Böning, G, Bartmann, H, Wängler, B, Nowak, S, Just, T et al.. Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar. Neuroimage. 2010;49 (2):1406-15. doi: 10.1016/j.neuroimage.2009.09.048. PubMed PMID:19796699 .
  99. Massarweh, G, Kovacevic, M, Rosa-Neto, P, Evans, AC, Diksic, M, Schirrmacher, R et al.. Time-efficient and convenient synthesis of [(18)F]altanserin for human PET imaging by a new work-up procedure. Appl Radiat Isot. 2009;67 (11):2040-3. doi: 10.1016/j.apradiso.2009.07.020. PubMed PMID:19692252 .
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  101. Rosa-Neto, P, Wängler, B, Iovkova, L, Boening, G, Reader, A, Jurkschat, K et al.. [18F]SiFA-isothiocyanate: a new highly effective radioactive labeling agent for lysine-containing proteins. Chembiochem. 2009;10 (8):1321-4. doi: 10.1002/cbic.200900132. PubMed PMID:19422010 .
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  103. Nicolakakis, N, Aboulkassim, T, Ongali, B, Lecrux, C, Fernandes, P, Rosa-Neto, P et al.. Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. J. Neurosci. 2008;28 (37):9287-96. doi: 10.1523/JNEUROSCI.3348-08.2008. PubMed PMID:18784309 .
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  106. Frey, BN, Rosa-Neto, P, Lubarsky, S, Diksic, M. Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study. Neuroimage. 2008;42 (2):850-7. doi: 10.1016/j.neuroimage.2008.05.009. PubMed PMID:18583156 .
  107. Chakravarty, MM, Rosa-Neto, P, Broadbent, S, Evans, AC, Collins, DL. Robust S1, S2, and thalamic activations in individual subjects with vibrotactile stimulation at 1.5 and 3.0 T. Hum Brain Mapp. 2009;30 (4):1328-37. doi: 10.1002/hbm.20598. PubMed PMID:18537113 .
  108. Chen, ZJ, He, Y, Rosa-Neto, P, Germann, J, Evans, AC. Revealing modular architecture of human brain structural networks by using cortical thickness from MRI. Cereb. Cortex. 2008;18 (10):2374-81. doi: 10.1093/cercor/bhn003. PubMed PMID:18267952 PubMed Central PMC2733312.
  109. Rosa-Neto, P, Benkelfat, C, Sakai, Y, Leyton, M, Morais, JA, Diksic, M et al.. Brain regional alpha-[11C]methyl-L-tryptophan trapping, used as an index of 5-HT synthesis, in healthy adults: absence of an age effect. Eur. J. Nucl. Med. Mol. Imaging. 2007;34 (8):1254-64. doi: 10.1007/s00259-007-0365-x. PubMed PMID:17318550 .
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  113. Rosa-Neto, P, Diksic, M, Leyton, M, Mzengeza, S, Benkelfat, C. Stability of alpha-[11C]methyl-L-tryptophan brain trapping in healthy male volunteers. Eur. J. Nucl. Med. Mol. Imaging. 2005;32 (10):1199-204. doi: 10.1007/s00259-005-1829-5. PubMed PMID:15948006 .
  114. Rosa-Neto, P, Lou, HC, Cumming, P, Pryds, O, Karrebaek, H, Lunding, J et al.. Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder. Neuroimage. 2005;25 (3):868-76. doi: 10.1016/j.neuroimage.2004.11.031. PubMed PMID:15808987 .
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  116. Rosa-Neto, P, Gjedde, A, Olsen, AK, Jensen, SB, Munk, OL, Watanabe, H et al.. MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain. Synapse. 2004;53 (4):222-33. doi: 10.1002/syn.20053. PubMed PMID:15266554 .
  117. Rosa-Neto, P, Olsen, AK, Gjedde, A, Watanabe, H, Cumming, P. MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia. Synapse. 2004;53 (4):214-21. doi: 10.1002/syn.20052. PubMed PMID:15266553 .
  118. Rosa-Neto, P, Doudet, DJ, Cumming, P. Gradients of dopamine D1- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET. Neuroimage. 2004;22 (3):1076-83. doi: 10.1016/j.neuroimage.2004.03.004. PubMed PMID:15219579 .
  119. Rosa-Neto, P, Diksic, M, Okazawa, H, Leyton, M, Ghadirian, N, Mzengeza, S et al.. Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Arch. Gen. Psychiatry. 2004;61 (6):556-63. doi: 10.1001/archpsyc.61.6.556. PubMed PMID:15184235 .
  120. Cumming, P, Rosa-Neto, P, Watanabe, H, Smith, D, Bender, D, Clarke, PB et al.. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. Neuroimage. 2003;19 (3):1127-36. . PubMed PMID:12880838 .
  121. Rosa Neto, P, Lou, H, Cumming, P, Pryds, O, Gjedde, A. Methylphenidate-evoked potentiation of extracellular dopamine in the brain of adolescents with premature birth: correlation with attentional deficit. Ann. N. Y. Acad. Sci. 2002;965 :434-9. . PubMed PMID:12105118 .
  122. Bernasconi, A, Martinez, V, Rosa-Neto, P, D'Agostino, D, Bernasconi, N, Berkovic, S et al.. Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results. Epilepsia. 2001;42 (9):1124-9. . PubMed PMID:11580758 .
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